Noone runs E85 here
I guess if you live in an area where it is available, you can try it. But it has some serious drawbacks that most people don't really like:
Bad economy, requires from 30-40% more fuel.
Not available, with frequent fill-ups if there isn't a station where you go you are stuck.
Requires fuel line change, and conversion for the alcohol.
Requires a larger fuel pump, and larger injectors. Sometimes to the point the car won't idle well below 1500+rpm.
Harder to start in the winter, hope you have a big battery.
All motor applications would be pretty cool to see with high compression though. A few of my friends run E85 in their cars. But here is a real big drawback: advertised ethanol concentration! Our pumps here say E85, but it is more like E60-70 where I am. This will mess with your tune.
I think E85 on a 13.5:1 motor would be pretty cool to see.