I f you want to run a 10 plus comp I would focus in to lower the temp in the combustion chamber , there are several ways to do it.
Like Andreas said I dont see probs to make 400 plus on a high comp motor.
My rr pistons have seen 25 plus lbs so many times that I cant count ... nothing have been happend , with the right parts and tune it can be done .
Cheers.