For me, 12.0:1 is the ratio to use when you're in the good parts of the compressor map. This is regardless of turbo size, power output, or boost level. If you're in the efficient islands of the map, you belong at 12.0:1. Once you start pushing off of the normal efficient range of the turbo and/or losing efficiency for other reasons (poor flow in intake or exhaust) then it can make sense to go richer (although really I'd rather see a more efficient setup instead). I think 11.5:1 is tolerable in those situations. If you're going past 11.0:1 then for me you're off the reservation.