The idea is to get rid of a heavy, limited valve train.
When that land speed record engine build detailed that, I thought it was a wonderful idea and it still is.
VVL valve train is heavy and without doing the mundane task of clearing every rocker with big cams, doing a delete is a grand idea.
It would not hurt low end anymore than running a single cam profile. But if it lightens the valvetrain, no it will not hurt low end. The question you asked can yield two answers (or more) depending on what answers you are looking for,
@MR-4Door-SR20DET