The sr20de/ve/det you name it can handle nitrous easy. The issue is your ? Is vague. Give us more info, budget, hp goal, car use.
I ran 125hp wet shot on a 180k junk yard sr20de motor a few times and it held. I even hit that same motor with 50hp shot plus 10psi of boost and it held for a few months.
50-75hp wet shot nitrous kit will be fine on the stock motor with stock timing of 15 degrees. 500-600$ new
100-150hp shot direct port with progressive control, stock motor is fine but you will need added fuel support, clutch, engine management and other supporting mods. 1500+$ depending on the system