You don't have to tune for one thing or another. An engine is an air pump, making it a more efficient pump means better MPGs (turbo's are great cruisers if you keep them off boost).
I have a feeling these cars can take a pretty lean cruise. In my 280z with a turbo swap, I ran close to 17:1 afr's at cruise. The head on that engine is close to 26 years old, and the design, who knows how much older. With that, I could break into the 30s with the 2.8l cruising at 80 mph.
My B13 SE-R right now just has what appears to be a pop charger and a busted flex coupling on the exhaust. With the tires inflated to 40 psi, I'm seeing about 28 mpg city, driving conservatively shifting at 3k, and trying not to get on it much. The car does see redline at least once every few days, and I make sure the air filter stays clean and the oil changed.
This car gives me 36 mpg freeway, and has even done 38 mpg 3 times on a 4-5hr trip. Right now it's my beater and I deliver in it and am still making money from my mileage payout!