Endurance racing reliability and 450 HP will come from keeping temps under control. It can be done with stock internals.
If you don't absolutely trust your tune or heat exchangers, then forged pistons are in your future. Might as well go with forged rods while you're at it.
If you do pistons I would raise the compression up from 8.5:1 (what you have now) to around 9.5:1 compression (what the N/A SR20 engines got stock) to help with boost onset. You're not making so much power that you need the lower compression.
You could look into an upgraded oil pump. There may be an easy way to get the higher pressure and higher flow SR20VE oil pump/front cover installed.
If you want to get into the head to do head work you can, but minimal work will be required if any.
Get some Jim Wolf Technologies S4 HL cams in there if your rules allow it.
That should do it for a reliable engine assuming a reliable tune and great cooling.
You can get 450 HP from a 3rd generation Garrett turbo (
GT3076 sized) very easily if you pay attention to the details. Delayed boost onset (which is what you're actually talking about, turbo lag is not the same) with this size of turbo is relatively minimal on the street, and almost non-existant at race RPM. So I wouldn't worry about that. Go for the 4th generation Garrett turbos (GTX series) and you will eliminate any worry of delayed boost onset.
Take care to get your Blow-Off Valve setup done right, and recirculated, and you should avoid common boost onset delays during shifts too.
Water Wetter has been tested and recommended by those racing SR20s in the past. It should be a safe bet for a bit of margin.
For a 1990s engine, the SR20 runs "normal" water temps. However, cars these days run MUCH hotter water temps. While our fans come on at 97C (really?) most engines these days aren't even getting into their stride until they are in the 102-105C area. The idea is fuel economy, but for a race car it can also mean power. Getting that fuel to atomize better with hot head temps works. Personally, I'd be happier with 100C temps than 95C. Just realize that 110C is getting warm, and 115C is time to shut it down.
Your radiator looks more than up to the task, so it will be down to ducting. Also, consider getting rid of all 3 of your fans, or keep maybe 1 if you must. The fans do absolutely nothing above ~30MPH and only hurt you above that speed.
EFR = Current turbocharger generation made by BorgWarner, comparable to the 4th-gen Garrett GTX turbos.
GTX = 4th-Gen (current) Garrett turbochargers.
GT = 3rd-gen Garrett turbochargers.